Welcome to M5BMachine 5-Minute Briefing

Introduction How do we identify latent groups of patients in a large cohort? How can we find similarities among patients that go beyond the well-known comorbidity clusters associated with specific diseases? And more importantly, how can we extract quantitative signals that can be analyzed, compared,...

Linear Regression looks simple, but it introduces the core ideas of modern machine learning: loss functions, optimization, gradients, scaling, and interpretation. In this article, we rebuild Linear Regression in Excel, compare the closed-form solution with Gradient Descent, and see how the coefficie...

OpenAI models have evolved drastically over the past few years. The journey began with GPT-3.5 and has now reached GPT-5.1 and the newer o-series reasoning models. While ChatGPT uses GPT-5.1 as its primary model, the API gives you access to many more options that are designed for different kinds of ...

Mistral AI’s latest announcement introduces DevStral 2 (123B parameters), DevStral Small 2 (24B), and the Mistral Vibe CLI, a terminal-native coding assistant built for agentic coding tasks. Both models are fully open source and tuned for production workflows, while the new Vibe CLI brings project-a...

The majority of people build machine learning models in an experimental or research setting, which is appropriate for exploration. It is not until you start to deploy it within real applications that you’ll see the actual value, for instance, a web application requesting predictions from your model,...

A lot of teams drown in scattered PDFs, scans, and odd-looking documents, trying to pull out the bits of information they actually need. LlamaExtract is here to their rescue. You upload your files, tell it what structure you want, and it hands back neat JSON that fits your schema. It works through a...